Development of a Novel Simulation Reactor for Chronic Exposure to Atmospheric Particulate Matter

نویسندگان

  • Jianhuai Ye
  • Sepehr Salehi
  • Michelle L. North
  • Anjelica M. Portelli
  • Chung-Wai Chow
  • Arthur W. H. Chan
چکیده

Epidemiological studies have shown that air pollution is associated with the morbidity and mortality from cardiopulmonary diseases. Currently, limited experimental models are available to evaluate the physiological and cellular pathways activated by chronic multi-pollutant exposures. This manuscript describes an atmospheric simulation reactor (ASR) that was developed to investigate the health effects of air pollutants by permitting controlled chronic in vivo exposure of mice to combined particulate and gaseous pollutants. BALB/c mice were exposed for 1 hr/day for 3 consecutive days to secondary organic aerosol (SOA, a common particulate air pollutant) at 10-150 μg/m3, SOA (30 μg/m3) + ozone (65 ppb) or SOA + ozone (65 ppb) + nitrogen dioxide (NO2; 100 ppb). Daily exposure to SOA alone led to increased airway hyperresponsiveness (AHR) to methacholine with increasing SOA concentrations. Multi-pollutant exposure with ozone and/or NO2 in conjunction with a sub-toxic concentration of SOA resulted in additive effects on AHR to methacholine. Inflammatory cell recruitment to the airways was not observed in any of the exposure conditions. The ASR developed in this study allows us to evaluate the chronic health effects of relevant multi-pollutant exposures at 'real-life' levels under controlled conditions and permits repeated-exposure studies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Exposure to Particulate Matter and its Health Impacts (an AirQ Approach)

Background & Aims of the Study: Recent studies indicated that particulate matter can have the lung irritation, chronic lung diseases, lung tissue, etc. The aim objective of this study was to assess the mortality associated with exposure to PM10 concentrations in Ilam, Iran, during 2013. Materials & Methods: PM10 data were taken from Ilam's ...

متن کامل

Health Impacts of Particulate Matter in Air using AirQ Model in Khorramabad City, Iran

Introduction: Air pollution due to particulate matter is a major environmental and health issue in all regions of the world. The aim of this study was to investigate the health impacts of PM10 (particulate matter with an aerodynamic diameter ≤10μm) in Khorramabad city, Iran in 2014. Materials and methods: In this study, PM10 sampling was conducted by a high-volume sampler at flow rate of 1.1-1...

متن کامل

Design of an Inhalation Chamber to Expose Laboratory Animals with Suspended Particulate Matter by Numerical Simulation Method

Introduction: Usually, in the toxicological studies of airborne particulate pollutants, inhalation exposure chambers are used for providing and distributing the test atmosphere uniformly and stability in the respiratory zone of laboratory animals. The purpose of this study was to design, evaluate and optimize a whole-body exposure chamber, specifically for small laboratory animals exposed to pa...

متن کامل

Atmospheric dispersion modeling and health effects of PM2.5 released from automotive industries (case study of Saipa)

Background: Air pollution is one of the most important environmental problems and various industries are sources of air pollutants, especially particulate matter. The purpose of this study is to evaluate the health effects of particulate matter released in the automotive industry. Methods: In this research, after measuring the concentrations with the WESTECH, monthly during 2021, the distributi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2017